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CHROMATAGRAPHIC, PHYTOCHEMICAL AND COMPARATIVE
ANTIMICROBIAL EVEALUATION OF STEM AND ROOT BARK EXTRACTS
OF GARCINIA KOLA
Falodun, A and Nwozigo, B.
Department of Pharmaceutical
Chemistry, Faculty of Pharmacy, University of Benin,
Benin City, Nigeria
2Department of Pharmaceutical
Chemistrry, Faculty of Pharmacy, Madonna University,
Elele, Nigeria.
faloabi@uniben.edu.
ABSTRACT
Garcinia kola is used in ethnomedicine for the treatment of a plothera
of diseases such as cough, bacteria infections and sexually tramsittted
diseases. This biological activity necessitated this present study in
order to justify its claimed traditional usage. Crude extract of the
plant and its fractions were obtained by solvent partitioning,
desolvated and subjected to phytochemical screening and chromatographic
profiling. The fractions of the stem and rootbark of the plant were
evaluated for their antimicrobial activity against some pathogenic
organism such E. coli, S. aereus, C. albicans, Klebsiella spp and
Samonella spp. The result of the study revealed the presence of some
secondary metabolities in the plant parts. The rootbark (MIC, 538mg/ml).
The antimicrobial activity of the root and stem bark of G. Kola lends
support to the traditional usage of the plant. |
