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AMELIORATION OF CADMIUM-INDUCED RENAL DYSFUNCTION
IN RATS: ROLE OF ANTIOXIDANT VITAMINS AND NIGERIAN-LIKE DIET.
Adaikpoh, M.A. and Obaseki D.E.
Department of Biochemistry,
Faculty of Science, University of Benin P.M.B 1154, Benin City, Nigeria
Department of Chemical
pathology, University of Benin Teaching Hospital UBTH,
Benin City, Nigeria.
tinadaikpoh@yahoo.com
ABSTRACT
In this study the ability of the
Nigerian-like diet and combined antioxidant vitamins C and E to repair
or prevent cadmium-indued impairment of renal function was examined in
rats (Wistar strain). Relative to the control, cadmiumsignifiantly
(p<0.05) increased urine volume and plasma K+ concentration
without any significant (p<0.05) effect on CI-, Na+
and HCO3- concentrations. Plasma urea and creatinine levels
were also significantly (p<0.05) increased while the SOD activity was
significantly (p<0.05) reduced in cadmium exposure. Treatment with
vitamins C and E after cadmium exposure significantly (p<0.05) reduced
CI- and HCO3- concentration. Although pretreatment
with vitamins C and E before cadmium significantly reduced (p<0.05) SOD
activity, MDA level was not significantly (p<0.05) increased. However,
histological examination of the kidney revealed mild tubular necrosis
with interstitial nephritis that was exacerbated by the vitamin
treatments. The Nigerian-like diet was more effective than either
pre-/post treatment of rats with vitamins C and E, at protecting the
kidney against cadmium mediated impairment of renal function.
Keywords: cadmium, electrolyte, tubular necrosis, renal function. |
